Comparative toxicities of different forms of asbestos on rat pleural mesothelial cells.
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چکیده
منابع مشابه
Comparative toxicities of different forms of asbestos on rat pleural mesothelial cells.
The effects of UICC crocidolite and chrysotile A, either oxalic acid-leached or unleached, on the viability, morphology and growth characteristics of rat pleural mesothelial cells (PMC) were examined; DQ12 quartz particles were also used. When asbestos fibers were added for 48 hr at the beginning of exponential growth, 20 or 50 micrograms/mL of chrysotile fibers were cytotoxic and no growth occ...
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The control of DNA integrity in mammalian cells is important to maintain the cell homeostasis and prevent neoplastic transformation. Control of cell division and cell death permits repair or elimination of damaged cells. Since asbestos fibers can produce DNA damage, chromosome alterations and apoptosis in several sorts of cells, including mesothelial cells, it was interesting to investigate cel...
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Mesothelial cells, the progenitor cell of the asbestos-induced tumor mesothelioma, are particularly sensitive to the toxic effects of asbestos, although the molecular mechanisms by which asbestos induces injury in mesothelial cells are not known. We asked whether asbestos induced apoptosis in mesothelial cells and whether reactive oxygen species were important. Pleural mesothelial cells (rabbit...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1983
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.8351153